Background: Spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. Transplantation of Schwann cells has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity. Furthermore, accessible sources such as bone marrow stem cells ...

Steroids promote the myelination and regeneration in the peripheral nervous system. Whereas, little is known about the inducing effects by which the hormones exert their effects on Schwann cells differentiation. This could be revealed by the expression of Schwann cell markers in adipose-derived stem cells (ADSCs). The purpose of this study was to present the effects of progesterone and 17 β-est...

objective(s): predegeneration is a standard technique to obtain mitotically activated and enriched cultures of schwann cells (scs). this study, for the first time, evaluated the impact of various duration of predegeneration on cell yield and enrichment of scs from dog peripheral nerve. materials and methods: dog sural nerves were subjected to 5, 10, 15 day-long in vitro predegeneration. the tot...

background: spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. transplantation of schwann cells has shown a great promising result for spinal cord injury (sci). however, harvesting schwann cell has been limited due to donor morbidity and limited expansion capacity. furthermore, accessible sources such as bone marrow stem cells ...

nowadays, cell -based and tissue engineered products have opened new horizons in treatment of incurable nervous system disorders. the number of studies on the role of schwann cells (sc) in treating nervous disorders is higher than other cell types. different protocols have been suggested for isolation and expansion of sc which most of them have used multiple growth factors, mitogens and fetal b...

Background: Adipose-derived stem cells (ADSCs) are a population of pluripotent cells used for tissue engineering purposes. The main purpose of the present study was to transdifferentiate the ADSCs to Schwann-like cells and to determine the intensity of apoptosis in ADSCs during the transdifferentiation process. Methods: ADSCs were isolated from the inguinal adipose tissue of adult rats and the ...

the p75 pan-neurotrophin receptor (p75ntr) plays a pivotal role in linking the immune system with the nervous system. p75ntr is required for the development of several characteristic features of allergic asthma. also p75ntr upregulated by reactive schwann cells after peripheral nerve injury. moreover p75ntr and rhoa play a critical role in the regulation of apoptosis. to determine whether the d...

Objective(s) Bone marrow is the traditional source of human multipotent mesenchymal stem cells (MSCs), but adipose tissue appears to be an alternative and more readily available source. In this study, rat adipose-derived stem cells (ADSCs) were induced to differentiate into Schwann-like cells and compared with rat bone marrow stem cells (BMSCs) for their Schwann-like cells differentiation pote...

Background: The purification of Schwann cells has proven to be a difficult process, with most methods requiring the use of special equipment. However, obtaining a sufficient number and high purity of Schwann cells is an integral aspect in their use for clinical application. Therefore, the aim of this study was to establish a simple and effective protocol for the isolation and purification of Sc...

objective(s) bone marrow is the traditional source of human multipotent mesenchymal stem cells (mscs), but adipose tissue appears to be an alternative and more readily available source. in this study, rat adipose-derived stem cells (adscs) were induced to differentiate into schwann-like cells and compared with rat bone marrow stem cells (bmscs) for their schwann-like cells differentiation poten...